Cyclosporin A ( NSC 290193 )

产品货号. M15224 CAS No. 59865-13-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Cyclosporin A
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.
产品描述

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.
同义词

NSC 290193
通路

Metabolic Enzyme/Protease
靶点

Phosphatase
受体

calcineurin phosphatase
研究领域

Inflammation/Immunology
适应症

——

CAS Number

59865-13-3
分子量

1202.64
分子式

C62H111N11O12
纯度

>98%(HPLC)
溶解度

Ethanol: 100 mg/mL warmed (83.15 mM); DMSO: 100 mg/mL warmed (83.15 mM)
SMILES

CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
化学全称

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

1.Handschumacher RE, et al. Science, 1984, 226(4674), 544-547.

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